Reactome | NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3

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NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:437051] cytoplasmic vesicle membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10170070
displayName	NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3
eventOf	[Pathway:R-RNO-3134975] Regulation of innate immune responses to cytosolic DNA - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-8948709] DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-3249392] NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-1604439] Dtx4 [cytosol] [EntityWithAccessionedSequence:R-RNO-3249366] Nlrp4 [cytosol] [Complex:R-RNO-2396004] STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3
output	[Complex:R-RNO-8948707] NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-3249392
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-3134975] Regulation of innate immune responses to cytosolic DNA
(precedingEvent)	[Reaction:R-RNO-8948709] DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3
(inferredTo)	[Reaction:R-HSA-3249392] NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3

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