Reactome | Regulation of innate immune responses to cytosolic DNA

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Regulation of innate immune responses to cytosolic DNA Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10224353
displayName	Regulation of innate immune responses to cytosolic DNA
eventOf	[Pathway:R-RNO-1834949] Cytosolic sensors of pathogen-associated DNA - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:259969] regulation of type I interferon production
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-3134946] DDX41 ubiquitination by TRIM21 - Rattus norvegicus [Reaction:R-RNO-1964496] STING binds TRIM32 or TRIM56 - Rattus norvegicus [Reaction:R-RNO-3134804] STING ubiquitination by TRIM32 or TRIM56 - Rattus norvegicus [Reaction:R-RNO-3249392] NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 - Rattus norvegicus [Reaction:R-RNO-8948709] DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-3134975] Regulation of innate immune responses to cytosolic DNA - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Regulation of innate immune responses to cytosolic DNA
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-3134975
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-1834949] Cytosolic sensors of pathogen-associated DNA
(inferredTo)	[Pathway:R-HSA-3134975] Regulation of innate immune responses to cytosolic DNA

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