Reactome | NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10205218] ubiquitin-protein transferase activity of NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane]
compartment	[Compartment:437051] cytoplasmic vesicle membrane
consumedByEvent	[Reaction:R-RNO-8948709] DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10166215
displayName	NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane]
hasComponent	[EntityWithAccessionedSequence:R-RNO-1604439] Dtx4 [cytosol] [EntityWithAccessionedSequence:R-RNO-3249366] Nlrp4 [cytosol] [Complex:R-RNO-2396004] STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-8948707] NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] - Homo sapiens
maxDepth	4
name	NLRP4:DTX4:STING:p-S172-TBK1:IRF3
negativelyRegulates	[NegativeRegulation:10166218] Negative regulation by 'NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane]'
producedByEvent	[Reaction:R-RNO-3249392] NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8948707
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(regulator)	[NegativeRegulation:10166218] Negative regulation by 'NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane]'
(input)	[Reaction:R-RNO-8948709] DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3
(physicalEntity)	[CatalystActivity:10205218] ubiquitin-protein transferase activity of NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane]
(output)	[Reaction:R-RNO-3249392] NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3
(inferredTo)	[Complex:R-HSA-8948707] NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane]