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Entries
Regulation of innate immune responses to cytosolic DNA
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authored
[InstanceEdit:3065946] Shamovsky, V, 2013-02-06
created
[InstanceEdit:3134976] Shamovsky, V, 2013-02-13
dbId
3134975
displayName
Regulation of innate immune responses to cytosolic DNA
edited
[InstanceEdit:3465604] Shamovsky, V, 2013-05-17
eventOf
[Pathway:R-HSA-1834949] Cytosolic sensors of pathogen-associated DNA - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:259969] regulation of type I interferon production
hasDiagram
false
hasEHLD
false
hasEvent
[Reaction:R-HSA-3134946] DDX41 ubiquitination by TRIM21 - Homo sapiens
[Reaction:R-HSA-1964496] STING binds TRIM32 or TRIM56 - Homo sapiens
[Reaction:R-HSA-3134804] STING ubiquitination by TRIM32 or TRIM56 - Homo sapiens
[Reaction:R-HSA-8948703] NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1 - Homo sapiens
[Reaction:R-HSA-3249392] NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 - Homo sapiens
[Reaction:R-HSA-3249386] DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1 - Homo sapiens
[Reaction:R-HSA-8948709] DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 - Homo sapiens
[Pathway:R-HSA-3248023] Regulation by TREX1 - Homo sapiens
isInDisease
false
isInferred
false
lastUpdatedDate
2016-12-21
literatureReference
[LiteratureReference:3632894] Immune Sensing of DNA
[LiteratureReference:3632892] Regulation of the cytosolic DNA-sensing system in innate immunity: a current view
maxDepth
3
modified
[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name
Regulation of innate immune responses to cytosolic DNA
orthologousEvent
[Pathway:R-MMU-3134975] Regulation of innate immune responses to cytosolic DNA - Mus musculus
[Pathway:R-CEL-3134975] Regulation of innate immune responses to cytosolic DNA - Caenorhabditis elegans
[Pathway:R-DME-3134975] Regulation of innate immune responses to cytosolic DNA - Drosophila melanogaster
[Pathway:R-GGA-3134975] Regulation of innate immune responses to cytosolic DNA - Gallus gallus
[Pathway:R-DRE-3134975] Regulation of innate immune responses to cytosolic DNA - Danio rerio
[Pathway:R-SSC-3134975] Regulation of innate immune responses to cytosolic DNA - Sus scrofa
[Pathway:R-BTA-3134975] Regulation of innate immune responses to cytosolic DNA - Bos taurus
[Pathway:R-CFA-3134975] Regulation of innate immune responses to cytosolic DNA - Canis familiaris
[Pathway:R-RNO-3134975] Regulation of innate immune responses to cytosolic DNA - Rattus norvegicus
releaseDate
2013-06-11
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:3110284] D'Eustachio, P, 2013-02-11
[InstanceEdit:3597627] Jin, Lei, 2013-05-21
[InstanceEdit:3597624] Wu, Jiaxi, 2013-05-21
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-3134975
summation
[Summation:3261238] Innate immune responses are coordinated and regulated to pro...
updateTrackers
[UpdateTracker:9786659] Update Tracker - [Pathway:3134975] Regulation of innate immune responses to cytosolic DNA - v49:[updateContainedPathway]
[UpdateTracker:9782153] Update Tracker - [Pathway:3134975] Regulation of innate immune responses to cytosolic DNA - v59:[addHasEvent, updateContainedRLE]
Referrals
(updatedInstance)
[UpdateTracker:9786659] Update Tracker - [Pathway:3134975] Regulation of innate immune responses to cytosolic DNA - v49:[updateContainedPathway]
[UpdateTracker:9782153] Update Tracker - [Pathway:3134975] Regulation of innate immune responses to cytosolic DNA - v59:[addHasEvent, updateContainedRLE]
(hasEvent)
[Pathway:R-HSA-1834949] Cytosolic sensors of pathogen-associated DNA
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