Reactome | BTRC:CUL1:RBX1:SKP1 [cytosol]

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BTRC:CUL1:RBX1:SKP1 [cytosol] Show undefined attributes

catalystActivities	[CatalystActivity:10127467] ubiquitin-protein transferase activity of BTRC:CUL1:RBX1:SKP1 [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-RNO-9012428] BTRC:CUL1:RBX1:SKP1:NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] - Rattus norvegicus [Complex:R-RNO-9929358] p-S184,T180-CD274:BTRC E3 complex [cytosol] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-1370500] PRLR binds SCF beta-TrCP complex - Rattus norvegicus [Reaction:R-RNO-9929357] p-S184,T180-CD274 binds to BTRC-SCF E3 ubiquitin ligase complex - Rattus norvegicus [Reaction:R-RNO-209125] SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex - Rattus norvegicus [Reaction:R-RNO-2130279] Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10127460
displayName	BTRC:CUL1:RBX1:SKP1 [cytosol]
hasComponent	[EntityWithAccessionedSequence:R-RNO-174237] Btrc [cytosol] [EntityWithAccessionedSequence:R-RNO-174230] Cul1 [cytosol] [EntityWithAccessionedSequence:R-RNO-180582] Rbx1 [cytosol] [EntityWithAccessionedSequence:R-RNO-174150] Skp1 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-206748] BTRC:CUL1:RBX1:SKP1 [cytosol] - Homo sapiens
maxDepth	2
name	BTRC:CUL1:RBX1:SKP1
producedByEvent	[BlackBoxEvent:R-RNO-1170539] Prolactin receptor is internalized - Rattus norvegicus [Reaction:R-RNO-9929352] Ubiquitinated CD274 is degraded by the 26S proteasome - Rattus norvegicus [BlackBoxEvent:R-RNO-2130282] Degradation of ubiquitinated beta catenin by the proteasome - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-206748
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(output)	[BlackBoxEvent:R-RNO-1170539] Prolactin receptor is internalized [Reaction:R-RNO-9929352] Ubiquitinated CD274 is degraded by the 26S proteasome [BlackBoxEvent:R-RNO-2130282] Degradation of ubiquitinated beta catenin by the proteasome
(input)	[Reaction:R-RNO-1370500] PRLR binds SCF beta-TrCP complex [Reaction:R-RNO-9929357] p-S184,T180-CD274 binds to BTRC-SCF E3 ubiquitin ligase complex [Reaction:R-RNO-209125] SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex [Reaction:R-RNO-2130279] Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex
(hasComponent)	[Complex:R-RNO-9929358] p-S184,T180-CD274:BTRC E3 complex [cytosol] [Complex:R-RNO-9012428] BTRC:CUL1:RBX1:SKP1:NFKB1:RELA:p-S32,S36-NFKBIA:Ub [cytosol] [Complex:R-RNO-206891] NFKB1(1-433):RELA:p-S32,S36-NFKBIA:BTRC:CUL1:RBX1:SKP1 [cytosol] [Complex:R-RNO-1369085] PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] [Complex:R-RNO-2130280] RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol]
(physicalEntity)	[CatalystActivity:10127467] ubiquitin-protein transferase activity of BTRC:CUL1:RBX1:SKP1 [cytosol]
(inferredTo)	[Complex:R-HSA-206748] BTRC:CUL1:RBX1:SKP1 [cytosol]

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