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SQSTM1 [cytosol]
Stable Identifier
R-RNO-193937
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
O08623
Locations in the PathwayBrowser
Expand all
Autophagy (Rattus norvegicus)
Macroautophagy (Rattus norvegicus)
Selective autophagy (Rattus norvegicus)
Mitophagy (Rattus norvegicus)
PINK1-PRKN Mediated Mitophagy (Rattus norvegicus)
LC3 binds the autophagosome membrane Atg5-Atg12 complex (Rattus norvegicus)
ATG5:ATG12:LC3:K48polyUB Mitophagy Substrates:SQSTM1 [phagocytic vesicle] (Rattus norvegicus)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Rattus norvegicus)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Rattus norvegicus)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
p62 binds ubiquitinated mitochondrial substrates (Rattus norvegicus)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
p62 links damaged mitochondria to LC3 (Rattus norvegicus)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
LC3:K48polyUB Mitophagy Substrates:SQSTM1 [cytosol] (Rattus norvegicus)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
Pexophagy (Rattus norvegicus)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1 (Rattus norvegicus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
ATM dimer:Ub-p-PEX5:SQSTM1:MAP1LC3B [peroxisomal membrane] (Rattus norvegicus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
MAP1LC3B binds ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 (Rattus norvegicus)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 [peroxisomal membrane] (Rattus norvegicus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1:MAP1LC3B [peroxisomal membrane] (Rattus norvegicus)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 [peroxisomal membrane] (Rattus norvegicus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
NBR1 binds ATM:Ub-p-PEX5:SQSTM1 (Rattus norvegicus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
ATM dimer:Ub-p-PEX5:SQSTM1:NBR1 [peroxisomal membrane] (Rattus norvegicus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
SQSTM1 binds ATM dimer:Ub-p-PEX5 (Rattus norvegicus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular response to chemical stress (Rattus norvegicus)
KEAP1-NFE2L2 pathway (Rattus norvegicus)
SQSTM1 oligomerizes (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
SQSTM1 oligomer [cytosol] (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
TRIM21 ubiquitinates SQSTM1 (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-1 family signaling (Rattus norvegicus)
Interleukin-1 signaling (Rattus norvegicus)
p62:MEKK3 binds to TRAF6 (Rattus norvegicus)
MAP3K3:SQSTM1 [cytosol] (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
MAP3K3:SQSTM1:TRAF6 [cytosol] (Rattus norvegicus)
MAP3K3:SQSTM1 [cytosol] (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Death Receptor Signaling (Rattus norvegicus)
p75 NTR receptor-mediated signalling (Rattus norvegicus)
Cell death signalling via NRAGE, NRIF and NADE (Rattus norvegicus)
NRIF signals cell death from the nucleus (Rattus norvegicus)
Polyubiquitinated NRIF binds to p62 (Sequestosome) (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
Ubiquitinated NRIF:Sequestosome [cytosol] (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
Polyubiquitinated NRIF migrates to the nucleus (Rattus norvegicus)
Ubiquitinated NRIF:Sequestosome [cytosol] (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
p75NTR signals via NF-kB (Rattus norvegicus)
NF-kB is activated and signals survival (Rattus norvegicus)
IKKbeta is activated (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
p75NTR recruits signalling complexes (Rattus norvegicus)
IKK-beta is recruited (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
TRAF6 is auto-ubiquitinated (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
p62 is recruited and forms a complex with TRAF6 (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
p62 recruits an atypical PKC (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
SQSTM1 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:O08623
Reference Genes
BioGPS Gene:113894
ENSEMBL:ENSRNOG00000003147
ENSEMBL:ENSRNOG00000003147.9
ENSEMBL:ENSRNOG00055019045
ENSEMBL:ENSRNOG00060019383
ENSEMBL:ENSRNOG00065006177
KEGG Gene (Rattus norvegicus):113894
Monarch:113894
NCBI Gene:113894
UCSC:O08623
Reference Transcript
RefSeq:NM_181550.1
RefSeq:XM_006246213.2
RefSeq:NM_175843.4
Other Identifiers
10742388
113894
1371353_at
17655823
5688996
5771715
5812280
5887002
5892734
5985891
6208154
6293429
6364872
6370461
6714878
A_44_P107199
A_44_P367550
A_44_P367551
A_44_P367556
GE1167050
GO:0000122
GO:0000407
GO:0000423
GO:0000425
GO:0000932
GO:0001659
GO:0005080
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005764
GO:0005773
GO:0005776
GO:0005829
GO:0005929
GO:0006351
GO:0006355
GO:0006366
GO:0006606
GO:0006886
GO:0006913
GO:0006914
GO:0007005
GO:0007032
GO:0008270
GO:0010508
GO:0016234
GO:0016235
GO:0016236
GO:0016605
GO:0019899
GO:0019901
GO:0023052
GO:0030163
GO:0030674
GO:0031397
GO:0031410
GO:0031625
GO:0034614
GO:0035255
GO:0035591
GO:0035973
GO:0036211
GO:0038023
GO:0042169
GO:0042802
GO:0043122
GO:0043130
GO:0043226
GO:0043231
GO:0044753
GO:0044754
GO:0046872
GO:0060089
GO:0060090
GO:0061635
GO:0061912
GO:0070342
GO:0070530
GO:0071211
GO:0072659
GO:0097009
GO:0097225
GO:0098780
GO:0140036
GO:1900273
GO:1903078
GO:1905719
ILMN_1376089
ILMN_1376894
PH_rn_0005032
Y08355cds#2_at
rc_AI180281_at
Participates
as an input of
TRIM21 ubiquitinates SQSTM1 (Rattus norvegicus)
SQSTM1 oligomerizes (Rattus norvegicus)
Polyubiquitinated NRIF binds to p62 (Sequestosome) (Rattus norvegicus)
p62 is recruited and forms a complex with TRAF6 (Rattus norvegicus)
SQSTM1 binds ATM dimer:Ub-p-PEX5 (Rattus norvegicus)
p62 binds ubiquitinated mitochondrial substrates (Rattus norvegicus)
as a component of
SQSTM1 oligomer [cytosol] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Rattus norvegicus)
Ubiquitinated NRIF:Sequestosome [cytosol] (Rattus norvegicus)
MAP3K3:SQSTM1 [cytosol] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Rattus norvegicus)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Rattus norvegicus)
ATM dimer:Ub-p-PEX5:SQSTM1 [peroxisomal membrane] (Rattus norvegicus)
K48polyUB Mitophagy Substrates:SQSTM1 [mitochondrial outer membrane] (Rattus norvegicus)
Other forms of this molecule
K7 ub-SQSTM1 [cytosol]
phospho-p-S349 SQSTM1 [cytosol]
phospho-ub K420 p-S349 SQSTM1 [cytosol]
SQSTM1 [nucleoplasm]
Inferred From
SQSTM1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_006246275.1
,
NP_787037.2
,
NP_853528.1
Ensembl
ENSRNOP00000004308
,
ENSRNOG00000003147
,
ENSRNOP00000056021
,
ENSRNOT00000059255
,
ENSRNOT00000004308
PRO
O08623
RGD
69287
PDB
2K6Q
,
2KTR
,
2KKC
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