Reactome | NRAGE signals death through JNK

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NRAGE signals death through JNK Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10223191
displayName	NRAGE signals death through JNK
eventOf	[Pathway:R-RNO-204998] Cell death signalling via NRAGE, NRIF and NADE - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:160565] positive regulation of apoptotic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-205039] p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor - Rattus norvegicus [Reaction:R-RNO-205136] GTP-bound RAC contributes to JNK activation - Rattus norvegicus [Reaction:R-RNO-205075] JNK phosphorylates BIM, BAD and other targets - Rattus norvegicus [Reaction:R-RNO-193666] Active JNK moves to the nucleus and phosphorylates different transcription factors - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-193648] NRAGE signals death through JNK - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	NRAGE signals death through JNK
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-193648
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-204998] Cell death signalling via NRAGE, NRIF and NADE
(inferredTo)	[Pathway:R-HSA-193648] NRAGE signals death through JNK

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