Reactome | Active JNK moves to the nucleus and phosphorylates different transcription factors

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Active JNK moves to the nucleus and phosphorylates different transcription factors Show undefined attributes

category	transition
compartment	[Compartment:13231] nuclear envelope
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10122472
displayName	Active JNK moves to the nucleus and phosphorylates different transcription factors
eventOf	[Pathway:R-RNO-193648] NRAGE signals death through JNK - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-193666] Active JNK moves to the nucleus and phosphorylates different transcription factors - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-194371] phospho-p-T,Y-MAPK8 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Active JNK moves to the nucleus and phosphorylates different transcription factors
output	[EntityWithAccessionedSequence:R-RNO-216349] phospho-p-T,Y-MAPK8 [nucleoplasm]
precedingEvent	[Reaction:R-RNO-193669] TRAF6 binds to p75NTR:NRIF - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-193666
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-193648] NRAGE signals death through JNK
(inferredTo)	[Reaction:R-HSA-193666] Active JNK moves to the nucleus and phosphorylates different transcription factors

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