Reactome | GTP-bound RAC contributes to JNK activation

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GTP-bound RAC contributes to JNK activation Show undefined attributes

category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10127303
displayName	GTP-bound RAC contributes to JNK activation
eventOf	[Pathway:R-RNO-193648] NRAGE signals death through JNK - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-205075] JNK phosphorylates BIM, BAD and other targets - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-205136] GTP-bound RAC contributes to JNK activation - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-RNO-168141] MAPK8 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	GTP-bound RAC contributes to JNK activation
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-RNO-194371] phospho-p-T,Y-MAPK8 [cytosol]
regulatedBy	[Requirement:10127304] Requirement by 'RAC1:GTP [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-205136
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-193648] NRAGE signals death through JNK
(precedingEvent)	[Reaction:R-RNO-205075] JNK phosphorylates BIM, BAD and other targets
(inferredTo)	[Reaction:R-HSA-205136] GTP-bound RAC contributes to JNK activation

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