Reactome | JNK phosphorylates BIM, BAD and other targets

Schema > Reaction > Entries

JNK phosphorylates BIM, BAD and other targets Show undefined attributes

catalystActivity	[CatalystActivity:10127271] JUN kinase activity of p-T,Y-MAPK8 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10127273
displayName	JNK phosphorylates BIM, BAD and other targets
eventOf	[Pathway:R-RNO-193648] NRAGE signals death through JNK - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-205075] JNK phosphorylates BIM, BAD and other targets - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [EntityWithAccessionedSequence:R-RNO-50662] Bad [cytosol] [EntityWithAccessionedSequence:R-RNO-2976673] Bcl2l11 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	JNK phosphorylates BIM, BAD and other targets
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-RNO-217297] phospho-Bad [cytosol] [EntityWithAccessionedSequence:R-RNO-2976671] phospho-Bcl2l11 [cytosol]
precedingEvent	[Reaction:R-RNO-205136] GTP-bound RAC contributes to JNK activation - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-205075
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-193648] NRAGE signals death through JNK
(inferredTo)	[Reaction:R-HSA-205075] JNK phosphorylates BIM, BAD and other targets

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