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p-2S-SMAD2,3:SMAD4 [nucleoplasm]
Stable Identifier
R-RNO-173511
Type
Set [DefinedSet]
Species
Rattus norvegicus
Compartment
nucleoplasm
Synonyms
Phospho-R-SMAD:CO-SMAD complex
Locations in the PathwayBrowser
Expand all
Developmental Biology (Rattus norvegicus)
Signaling by NODAL (Rattus norvegicus)
Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Rattus norvegicus)
SMAD2,3:SMAD4:FOXO3:FoxO3a-binding Element [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
FOXO-mediated transcription (Rattus norvegicus)
FOXO-mediated transcription of cell cycle genes (Rattus norvegicus)
FOXG1 binds FOXO:SMAD complexes (Rattus norvegicus)
FOXG1:FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Rattus norvegicus)
FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Rattus norvegicus)
FOXO1,FOXO3,FOXO4:p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Rattus norvegicus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Rattus norvegicus)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
PARP1 binds SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
PPM1A dephosphorylates nuclear SMAD2/3 (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
p-SMAD2,3:SMAD4:TRIM33 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
TRIM33 monoubiquitinates SMAD4 (Rattus norvegicus)
p-SMAD2,3:SMAD4:TRIM33 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Rattus norvegicus)
MEN1 binds SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4:MEN1 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
SMAD2/3:SMAD4 heterotrimer binds SP1 (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4:SP1 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
WWTR1:SMAD translocates to the nucleus (Rattus norvegicus)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by TGFB family members (Rattus norvegicus)
Signaling by Activin (Rattus norvegicus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
Signaling by TGF-beta Receptor Complex (Rattus norvegicus)
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer (Rattus norvegicus)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (Rattus norvegicus)
PARP1 ADP-ribosylates SMAD3 and SMAD4 (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
PARP1 binds SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
PPM1A dephosphorylates nuclear SMAD2/3 (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
p-SMAD2,3:SMAD4:TRIM33 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
TRIM33 monoubiquitinates SMAD4 (Rattus norvegicus)
p-SMAD2,3:SMAD4:TRIM33 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription (Rattus norvegicus)
MEN1 binds SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4:MEN1 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
SMAD2/3:SMAD4 heterotrimer binds SP1 (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4:SP1 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
The SMAD2/3:SMAD4 complex transfers to the nucleus (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
WWTR1:SMAD translocates to the nucleus (Rattus norvegicus)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
Participants
members
p-2S-SMAD3:p-2S-SMAD3:SMAD4 [nucleoplasm]
(Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD2:SMAD4 [nucleoplasm]
(Rattus norvegicus)
p-2S-SMAD2:p-2S-SMAD3:SMAD4 [nucleoplasm]
(Rattus norvegicus)
Participates
as an input of
Phospho R-SMAD(SMAD2/3):CO-SMAD(SMAD4):FOXO3 binds FoxO3a-binding elements (Rattus norvegicus)
MEN1 binds SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)
Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling (Rattus norvegicus)
PPM1A protein phosphatase binds phosphorylated SMAD2/3 (Rattus norvegicus)
PARP1 binds SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)
TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer (Rattus norvegicus)
SMAD2/3:SMAD4 heterotrimer binds SP1 (Rattus norvegicus)
SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2 (Rattus norvegicus)
FOXO1,FOXO3,FOXO4 bind p-2S-SMAD2/3:SMAD4 (Rattus norvegicus)
Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9 (Rattus norvegicus)
SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling (Rattus norvegicus)
TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus (Rattus norvegicus)
as a component of
SMAD2,3:SMAD4:FOXO3:FoxO3a-binding Element [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4:MEN1 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4:PPM1A [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4:PARP1 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4:SP1 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4:RBL1:E2F4,5:DP1,2 [nucleoplasm] (Rattus norvegicus)
WWTR1:p-2S-SMAD2,3:SMAD4 [nucleoplasm] (Rattus norvegicus)
p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] (Rattus norvegicus)
p-SMAD2,3:SMAD4:TRIM33 [nucleoplasm] (Rattus norvegicus)
FOXO1,FOXO3,FOXO4:p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Rattus norvegicus)
FOXO3,(FOXO1,FOXO4):p-2S-SMAD2/3:SMAD4 [nucleoplasm] (Rattus norvegicus)
as an output of
The SMAD2/3:SMAD4 complex transfers to the nucleus (Rattus norvegicus)
Inferred From
p-2S-SMAD2,3:SMAD4 [nucleoplasm]
(Homo sapiens)
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