Reactome | TNF-?:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane]

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TNF-?:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-RNO-5357866] TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] - Rattus norvegicus [Complex:R-RNO-9796354] TNF-?:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-9796342] MIB2 binds RIPK1 within TNF-?:TNFR1:TRADD:RIPK1:TRAF2 - Rattus norvegicus [Reaction:R-RNO-83582] TRADD:TRAF2:RIP1 dissociates from TNF-?:TNFR1 - Rattus norvegicus [Reaction:R-RNO-5357780] TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10110631
displayName	TNF-?:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane]
hasComponent	[EntityWithAccessionedSequence:R-RNO-168651] Ripk1 [cytosol] [DefinedSet:R-RNO-3371401] TNF-? trimer:TNFR1 trimer [plasma membrane] 3 × [EntityWithAccessionedSequence:R-RNO-66376] Tradd [cytosol] 3 × [EntityWithAccessionedSequence:R-RNO-66370] Traf2 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-140946] TNF-?:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane] - Homo sapiens
maxDepth	5
memberOf	[DefinedSet:R-RNO-5693112] RIPK1-containg TNFR1 signaling complexes [plasma membrane] - Rattus norvegicus
name	TNF-?:TNFR1:TRADD:RIPK1:TRAF2
producedByEvent	[BlackBoxEvent:R-RNO-9818975] CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex - Rattus norvegicus [Reaction:R-RNO-83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1 - Rattus norvegicus [BlackBoxEvent:R-RNO-9817400] CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-140946
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(output)	[BlackBoxEvent:R-RNO-9817400] CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex [BlackBoxEvent:R-RNO-9818975] CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex [Reaction:R-RNO-83656] TNF:TNFR1 binds TRADD, TRAF2 and RIPK1
(input)	[Reaction:R-RNO-9796342] MIB2 binds RIPK1 within TNF-?:TNFR1:TRADD:RIPK1:TRAF2 [Reaction:R-RNO-5357780] TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) [Reaction:R-RNO-83582] TRADD:TRAF2:RIP1 dissociates from TNF-?:TNFR1
(hasComponent)	[Complex:R-RNO-9796354] TNF-?:TNFR1:TRADD:RIPK1:TRAF2:MIB2:Ub:UBE2D1 [plasma membrane] [Complex:R-RNO-5357866] TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane]
(hasMember)	[DefinedSet:R-RNO-5693112] RIPK1-containg TNFR1 signaling complexes [plasma membrane]
(inferredTo)	[Complex:R-HSA-140946] TNF-?:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane]

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