Reactome | TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10176551] ubiquitin-protein transferase activity of TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[BlackBoxEvent:R-RNO-5357757] BIRC(cIAP1/2) ubiquitinates RIPK1 - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10176548
displayName	TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane]
hasComponent	[CandidateSet:R-RNO-5357900] BIRC2,3,4 [cytosol] [Complex:R-RNO-140946] TNF-?:TNFR1:TRADD:RIPK1:TRAF2 [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-5357866] TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane] - Homo sapiens
maxDepth	6
memberOf	[DefinedSet:R-RNO-5693112] RIPK1-containg TNFR1 signaling complexes [plasma membrane] - Rattus norvegicus
name	TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3
producedByEvent	[BlackBoxEvent:R-RNO-5357845] K63polyUb-RIPK1 is deubiquitinated - Rattus norvegicus [Reaction:R-RNO-5357780] TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5357866
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(hasMember)	[DefinedSet:R-RNO-5693112] RIPK1-containg TNFR1 signaling complexes [plasma membrane]
(output)	[BlackBoxEvent:R-RNO-5357845] K63polyUb-RIPK1 is deubiquitinated [Reaction:R-RNO-5357780] TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2)
(input)	[BlackBoxEvent:R-RNO-5357757] BIRC(cIAP1/2) ubiquitinates RIPK1
(physicalEntity)	[CatalystActivity:10176551] ubiquitin-protein transferase activity of TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane]
(inferredTo)	[Complex:R-HSA-5357866] TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane]