Reactome | (BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol]

Schema > DefinedSet > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-RNO-3000340] p-8S,3T-BORA:SCF-beta-TrCp1/2 [cytosol] - Rattus norvegicus [Complex:R-RNO-1168617] NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-3000339] Phosphorylated BORA binds SCF-beta-TrCp1/2 - Rattus norvegicus [Reaction:R-RNO-5684248] SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2 - Rattus norvegicus [Reaction:R-RNO-1168642] SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10151211
displayName	(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol]
hasMember	[Complex:R-RNO-174155] BTRC:CUL1:SKP1 [cytosol] - Rattus norvegicus [Complex:R-RNO-1168592] CUL1:FBXW11:SKP1 [cytosol] - Rattus norvegicus
inDisease	false
inferredFrom	[DefinedSet:R-HSA-1168601] (BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] - Homo sapiens
maxDepth	3
name	(BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) SCF-beta-TrCp1,2 SCF-beta-TrCp1 or SCF-beta-TrCP2
producedByEvent	[Reaction:R-RNO-3000335] SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA - Rattus norvegicus [BlackBoxEvent:R-RNO-1168643] SCF-beta-TrCP ubiquitinylates IkB - Rattus norvegicus [Reaction:R-RNO-5684250] SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2 - Rattus norvegicus
schemaClass	DefinedSet
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1168601

(output)	[Reaction:R-RNO-3000335] SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA [BlackBoxEvent:R-RNO-1168643] SCF-beta-TrCP ubiquitinylates IkB [Reaction:R-RNO-5684250] SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2
(activeUnit)	[CatalystActivity:10168847] ubiquitin-protein transferase activity of p-8S,3T-BORA:SCF-beta-TrCp1/2 [cytosol] [CatalystActivity:10183678] ubiquitin-protein transferase activity of SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol]
(input)	[Reaction:R-RNO-3000339] Phosphorylated BORA binds SCF-beta-TrCp1/2 [Reaction:R-RNO-1168642] SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB [Reaction:R-RNO-5684248] SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2
(hasComponent)	[Complex:R-RNO-3000340] p-8S,3T-BORA:SCF-beta-TrCp1/2 [cytosol] [Complex:R-RNO-1168617] NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] [Complex:R-RNO-5684270] SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol]
(inferredTo)	[DefinedSet:R-HSA-1168601] (BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol]