Reactome | UBA1 conjugates ubiquitin to nuclear E2 enzymes

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UBA1 conjugates ubiquitin to nuclear E2 enzymes Show undefined attributes

category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
dbId	11124269
displayName	UBA1 conjugates ubiquitin to nuclear E2 enzymes
eventOf	[Pathway:R-PFA-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes - Plasmodium falciparum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8852130] UBA1 conjugates ubiquitin to nuclear E2 enzymes - Homo sapiens
input	[DefinedSet:R-PFA-8852109] E2 ubiquitin conjugating enzyme (UBA1 substrate) [nucleoplasm] [Complex:R-PFA-8852059] Ub-Cys632-UBA1:ubiquitin adenylate [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	UBA1 conjugates ubiquitin to nuclear E2 enzymes
output	[Complex:R-PFA-8864169] Ub:E2 (UBA1 substrate) [nucleoplasm] [Complex:R-PFA-8852055] UBA1:ubiquitin adenylate [nucleoplasm]
precedingEvent	[Reaction:R-PFA-8852131] Ub-Cys632-UBA1 adenylates ubiquitin in the nucleus - Plasmodium falciparum
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170928] Plasmodium falciparum
stId	R-PFA-8852130
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-PFA-8866652] Synthesis of active ubiquitin: roles of E1 and E2 enzymes
(inferredTo)	[Reaction:R-HSA-8852130] UBA1 conjugates ubiquitin to nuclear E2 enzymes

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