Cyclin-dependent kinase 5 (CDK5) phosphorylates CLOCK on ser...

created [InstanceEdit:9928748] May, Bruce, 2024-11-17
dbId 9928750
displayName Cyclin-dependent kinase 5 (CDK5) phosphorylates CLOCK on ser...
literatureReference
modified [InstanceEdit:9934287] May, Bruce, 2025-01-07
schemaClass Summation
text Cyclin-dependent kinase 5 (CDK5) phosphorylates CLOCK on serine-451 and serine-461 (assayed with mouse Cdk5 and human CLOCK in Kwak et al. 2013). The phosphorylation causes nuclear translocation of CLOCK and increases transcriptional activation by the BMAL1:CLOCK complex (Kwak et al. 2013).
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