Activated Ntrk3 stimulates PI3K activity

Stable Identifier
R-NUL-9616944
Type
Reaction [omitted]
Species
Mus musculus
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
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PNG
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Activated Ntrk3 stimulates PI3K activity
PI3K signaling in mouse cells is stimulated by Ntrk3 (TrkC) activation and requires Src and/or Irs1 (Tognon et al. 2001, Jin et al. 2008).
Literature References
PubMed ID Title Journal Year
17991742 c-Src is required for tropomyosin receptor kinase C (TrkC)-induced activation of the phosphatidylinositol 3-kinase (PI3K)-AKT pathway

Jin, W, Yun, C, Jeong, J, Park, Y, Lee, HD, Kim, SJ

J. Biol. Chem. 2008
11751416 The chimeric protein tyrosine kinase ETV6-NTRK3 requires both Ras-Erk1/2 and PI3-kinase-Akt signaling for fibroblast transformation

Tognon, C, Garnett, M, Kenward, E, Kay, R, Morrison, K, Sorensen, PH

Cancer Res. 2001
Participants
Input
Output
Catalyst Activity

1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Pik3ca:Pik3r1 [cytosol]

Physical Entity
Pik3ca:Pik3r1 [cytosol] (Mus musculus)
Activity
1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)
This event is regulated
Positively by
Regulator
bNTF3:p-5Y-Ntrk3 homodimer:MyrG-p-Y424-Src,(bNTF3:p-5Y-Ntrk3 homodimer,bNTF3:p-5Y-Ntrk3 homodimer:MyrG-p-Y424-Src):Irs1 [plasma membrane] (Bos taurus)
Orthologous Events
Activated NTRK3 stimulates PI3K activity (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-01-02)
Reviewed
Tsoulfas, P  (2018-05-09)
Created
Orlic-Milacic, M  (2018-08-15)
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