Reactome | Activated ERKs phosphorylate Runx2

Schema > Reaction > Entries

authored	[InstanceEdit:9009237] Orlic-Milacic, Marija, 2017-06-16
catalystActivity	[CatalystActivity:9009251] protein serine/threonine kinase activity of p-Y185,Y187 MAPK1 dimer [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9009237] Orlic-Milacic, Marija, 2017-06-16
dbId	9009236
displayName	Activated ERKs phosphorylate Runx2
edited	[InstanceEdit:9015332] Orlic-Milacic, Marija, 2017-08-09
input	2 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [CandidateSet:R-MMU-9007832] Runx2 [nucleoplasm]
isChimeric	true
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9009204] Identification and functional characterization of ERK/MAPK phosphorylation sites in the Runx2 transcription factor
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activated ERKs phosphorylate Runx2
orthologousEvent	[Reaction:R-HSA-9009208] Activated ERKs phosphorylate RUNX2 - Homo sapiens
output	2 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [CandidateSet:R-MMU-9009198] p-2S-Runx2 [nucleoplasm]
releaseDate	2017-09-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9015314] Ducy, Patricia, 2017-08-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens [Species:48892] Mus musculus
stId	R-NUL-9009236
summation	[Summation:9009249] Recombinant mouse Runx2-P1 isoform is phosphorylated by reco...
updateTrackers	[UpdateTracker:9779272] Update Tracker - [Reaction:9009236] Activated ERKs phosphorylate Runx2 - v66:[addInput, addOutput]

(updatedInstance)

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