Reactome | PTK6 phosphorylates PXN

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PTK6 phosphorylates PXN Show undefined attributes

catalystActivity	[CatalystActivity:10075022] protein tyrosine kinase activity of p-Y342-PTK6:PXN [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10075024
displayName	PTK6 phosphorylates PXN
eventOf	[Pathway:R-MMU-8849471] PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-8848611] Phosphorylated PXN recruits the CRK complex - Mus musculus
inferredFrom	[Reaction:R-HSA-8848606] PTK6 phosphorylates PXN - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-8848597] p-Y342-PTK6:PXN [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PTK6 phosphorylates PXN
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [EntityWithAccessionedSequence:R-MMU-9709374] p-Y342-Ptk6 [cytosol] [EntityWithAccessionedSequence:R-MMU-5218693] phospho-Pxn [cytosol]
precedingEvent	[Reaction:R-MMU-8848596] PTK6 binds PXN - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-8848606
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8849471] PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
(precedingEvent)	[Reaction:R-MMU-8848611] Phosphorylated PXN recruits the CRK complex
(inferredTo)	[Reaction:R-HSA-8848606] PTK6 phosphorylates PXN