Reactome | Phosphorylated PXN recruits the CRK complex

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Phosphorylated PXN recruits the CRK complex Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10075028
displayName	Phosphorylated PXN recruits the CRK complex
eventOf	[Pathway:R-MMU-8849471] PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-8848618] Activation of RAC1 by the PXN:CRK complex - Mus musculus
inferredFrom	[Reaction:R-HSA-8848611] Phosphorylated PXN recruits the CRK complex - Homo sapiens
input	[Complex:R-MMU-2029141] CRK:DOCK180:ELMO1,ELMO2 [cytosol] [EntityWithAccessionedSequence:R-MMU-5218693] phospho-Pxn [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylated PXN recruits the CRK complex
output	[Complex:R-MMU-8848613] p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol]
precedingEvent	[Reaction:R-MMU-8848606] PTK6 phosphorylates PXN - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-8848611
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8849471] PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
(precedingEvent)	[Reaction:R-MMU-8848618] Activation of RAC1 by the PXN:CRK complex
(inferredTo)	[Reaction:R-HSA-8848611] Phosphorylated PXN recruits the CRK complex

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