Reactome | FasL/ CD95L signaling

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FasL/ CD95L signaling Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10098557
displayName	FasL/ CD95L signaling
eventOf	[Pathway:R-MMU-73887] Death Receptor Signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:2133497] apoptotic signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-MMU-75244] FASL binds FAS Receptor - Mus musculus [Reaction:R-MMU-71050] Trimerization of the FASL:FAS receptor complex - Mus musculus [Reaction:R-MMU-83650] FasL:Fas binds FADD - Mus musculus [Reaction:R-MMU-83586] FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 - Mus musculus
inferredFrom	[Pathway:R-HSA-75157] FasL/ CD95L signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	FasL/ CD95L signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-75157
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEncapsulatedEvent)	[Pathway:R-MMU-5357769] Caspase activation via extrinsic apoptotic signalling pathway [Pathway:R-MMU-5633008] TP53 Regulates Transcription of Cell Death Genes
(hasEvent)	[Pathway:R-MMU-73887] Death Receptor Signaling
(inferredTo)	[Pathway:R-HSA-75157] FasL/ CD95L signaling

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