Reactome | GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors

Schema > Reaction > Entries

GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10017437
displayName	GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors
eventOf	[Pathway:R-MMU-373076] Class A/1 (Rhodopsin-like receptors) - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-749448] Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq - Mus musculus
inferredFrom	[Reaction:R-HSA-444731] GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors - Homo sapiens
input	[SimpleEntity:R-ALL-351626] H+ [extracellular region] [DefinedSet:R-MMU-444736] pH sensing receptors [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors
output	[Complex:R-MMU-444739] pH sensing receptors:H+ [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-444731
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-373076] Class A/1 (Rhodopsin-like receptors)
(precedingEvent)	[Reaction:R-MMU-749448] Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
(inferredTo)	[Reaction:R-HSA-444731] GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors

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