Reactome | PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose

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PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose Show undefined attributes

catalystActivity	[CatalystActivity:9988890] purine-nucleoside phosphorylase activity of PNP trimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9988892
displayName	PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose
eventOf	[Pathway:R-MMU-74259] Purine catabolism - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-74247] XDH oxidizes hypoxanthine to form xanthine - Mus musculus [Reaction:R-MMU-9727347] XDH dehydrogenates hypoxanthine to form xanthine - Mus musculus
inferredFrom	[Reaction:R-HSA-74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose - Homo sapiens
input	[DefinedSet:R-ALL-500172] Ino, dI [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose inosine + phosphate => alpha-D-ribose 1-phosphate + hypoxanthine 2'-deoxyinosine + phosphate => 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine
output	[SimpleEntity:R-ALL-113599] Hyp [cytosol] [DefinedSet:R-ALL-500244] R1P, dRibP [cytosol]
precedingEvent	[Reaction:R-MMU-74241] ADA catalyzes the deamination of (deoxy)adenosine - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-74242
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-74259] Purine catabolism
(precedingEvent)	[Reaction:R-MMU-74247] XDH oxidizes hypoxanthine to form xanthine [Reaction:R-MMU-9727347] XDH dehydrogenates hypoxanthine to form xanthine
(inferredTo)	[Reaction:R-HSA-74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose

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