Reactome | XDH dehydrogenates hypoxanthine to form xanthine

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XDH dehydrogenates hypoxanthine to form xanthine Show undefined attributes

catalystActivity	[CatalystActivity:10091582] hypoxanthine dehydrogenase activity of XDH dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10091584
displayName	XDH dehydrogenates hypoxanthine to form xanthine
eventOf	[Pathway:R-MMU-74259] Purine catabolism - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-9727349] XDH dehydrogenates xanthine to form urate - Mus musculus
inferredFrom	[Reaction:R-HSA-9727347] XDH dehydrogenates hypoxanthine to form xanthine - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-113599] Hyp [cytosol] [SimpleEntity:R-ALL-29360] NAD+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	XDH dehydrogenates hypoxanthine to form xanthine hypoxanthine + NAD(+) + H2O => xanthine + NADH + H(+)
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73473] NADH [cytosol] [SimpleEntity:R-ALL-30064] XAN [cytosol]
precedingEvent	[Reaction:R-MMU-74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9727347
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-74259] Purine catabolism
(precedingEvent)	[Reaction:R-MMU-9727349] XDH dehydrogenates xanthine to form urate
(inferredTo)	[Reaction:R-HSA-9727347] XDH dehydrogenates hypoxanthine to form xanthine

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