Reactome | ADA catalyzes the deamination of (deoxy)adenosine

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ADA catalyzes the deamination of (deoxy)adenosine Show undefined attributes

catalystActivity	[CatalystActivity:9988875] deaminase activity of ADA [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9988877
displayName	ADA catalyzes the deamination of (deoxy)adenosine
eventOf	[Pathway:R-MMU-74217] Purine salvage - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose - Mus musculus
inferredFrom	[Reaction:R-HSA-74241] ADA catalyzes the deamination of (deoxy)adenosine - Homo sapiens
input	[DefinedSet:R-ALL-500173] Ade-Rib, dA [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ADA catalyzes the deamination of (deoxy)adenosine adenosine + H2O + H(+) => inosine + NH4(+) 2'-deoxyadenosine + H2O + H(+) => 2'-deoxyinosine + NH4(+) (2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH4+ (ADA)
output	[DefinedSet:R-ALL-500172] Ino, dI [cytosol] [SimpleEntity:R-ALL-31633] NH4+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-74241
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-74217] Purine salvage
(precedingEvent)	[Reaction:R-MMU-74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose
(inferredTo)	[Reaction:R-HSA-74241] ADA catalyzes the deamination of (deoxy)adenosine

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