Reactome | PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose

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PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose Show undefined attributes

catalystActivity	[CatalystActivity:74238] purine-nucleoside phosphorylase activity of PNP trimer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643298] purine-nucleoside phosphorylase activity of NP trimer [cytosol] Characterization of purine nucleoside phosphorylase from human granulocytes and its metabolism of deoxyribonucleosides
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:74183] Jassal, B, 2003-07-17 08:31:43
crossReference	[DatabaseIdentifier:11880299] Rhea:27647
dbId	74242
displayName	PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose
eventOf	[Pathway:R-HSA-74259] Purine catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-9727347] XDH dehydrogenates hypoxanthine to form xanthine - Homo sapiens [FailedReaction:R-HSA-9734274] Defective HPRT1 does not convert guanine or hypoxanthine to GMP or IMP - Homo sapiens [Reaction:R-HSA-74247] XDH oxidizes hypoxanthine to form xanthine - Homo sapiens
input	[DefinedSet:R-ALL-500172] Ino, dI [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:112023] Characterization of purine nucleoside phosphorylase from human granulocytes and its metabolism of deoxyribonucleosides [LiteratureReference:112027] A human purine nucleoside phosphorylase deficiency caused by a single base change [LiteratureReference:112018] Three-dimensional structure of human erythrocytic purine nucleoside phosphorylase at 3.2 A resolution
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose (deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate (NP)
orthologousEvent	[Reaction:R-GGA-421174] inosine + orthophosphate <=> hypoxanthine + D-ribose 1-phosphate - Gallus gallus [Reaction:R-SCE-74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose - Saccharomyces cerevisiae [Reaction:R-SPO-74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose - Schizosaccharomyces pombe [Reaction:R-CEL-74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose - Caenorhabditis elegans [Reaction:R-DME-74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose - Drosophila melanogaster [Reaction:R-XTR-74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose - Xenopus tropicalis [Reaction:R-DRE-74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose - Danio rerio [Reaction:R-SSC-74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose - Sus scrofa [Reaction:R-BTA-74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose - Bos taurus [Reaction:R-CFA-74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose - Canis familiaris [Reaction:R-RNO-74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose - Rattus norvegicus [Reaction:R-MMU-74242] PNP catalyzes the conversion of (deoxy)inosine to hypoxanthine and (deoxy)ribose - Mus musculus
output	[SimpleEntity:R-ALL-113599] Hyp [cytosol] [DefinedSet:R-ALL-500244] R1P, dRibP [cytosol]
precedingEvent	[Reaction:R-HSA-74241] ADA catalyzes the deamination of (deoxy)adenosine - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-74242
summation	[Summation:178306] Cytosolic purine nucleoside phosphorylase (PNP) trimer catal...

Referrals

(normalReaction)	[FailedReaction:R-HSA-9735775] Defective PNP does not convert (deoxy)inosine to hypoxanthine and (deoxy)ribose
(hasEvent)	[Pathway:R-HSA-74259] Purine catabolism
(precedingEvent)	[Reaction:R-HSA-9727347] XDH dehydrogenates hypoxanthine to form xanthine [FailedReaction:R-HSA-9734274] Defective HPRT1 does not convert guanine or hypoxanthine to GMP or IMP [Reaction:R-HSA-74247] XDH oxidizes hypoxanthine to form xanthine
(reverseReaction)	[Reaction:R-HSA-112033] PNP catalyzes the conversion of hypoxanthine and (deoxy)ribose to (deoxy)inosine

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