Reactome | HGD dioxygenates homogentisate

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HGD dioxygenates homogentisate Show undefined attributes

catalystActivity	[CatalystActivity:9986952] homogentisate 1,2-dioxygenase activity of HGD hexamer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9986954
displayName	HGD dioxygenates homogentisate
eventOf	[Pathway:R-MMU-8963684] Tyrosine catabolism - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-71173] GSTZ1 isomerizes 4-MAA - Mus musculus
inferredFrom	[Reaction:R-HSA-71164] HGD dioxygenates homogentisate - Homo sapiens
input	[SimpleEntity:R-ALL-30337] HGTA [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	HGD dioxygenates homogentisate homogentisate + O2 => 4-maleylacetoacetate + H(+) homogentisate + O2 => maleylacetoacetate
output	[SimpleEntity:R-ALL-31135] 4MAA [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[Reaction:R-MMU-71163] HPD dioxygenates HPP - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-71164
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8963684] Tyrosine catabolism
(precedingEvent)	[Reaction:R-MMU-71173] GSTZ1 isomerizes 4-MAA
(inferredTo)	[Reaction:R-HSA-71164] HGD dioxygenates homogentisate

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