Reactome | HGD dioxygenates homogentisate

Schema > Reaction > Entries

HGD dioxygenates homogentisate Show undefined attributes

authored	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
catalystActivity	[CatalystActivity:71084] homogentisate 1,2-dioxygenase activity of HGD hexamer [cytosol]
catalystActivityReference	[CatalystActivityReference:9643129] homogentisate 1,2-dioxygenase activity of HGD hexamer [cytosol] The molecular basis of alkaptonuria
category	transition
compartment	[Compartment:70101] cytosol
crossReference	[DatabaseIdentifier:12667821] RHEA:15450 [DatabaseIdentifier:9855289] RHEA:15450
dbId	71164
displayName	HGD dioxygenates homogentisate
edited	[InstanceEdit:73677] D'Eustachio, P, 2003-06-24 00:00:00
eventOf	[Pathway:R-HSA-8963684] Tyrosine catabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-71173] GSTZ1 isomerizes 4-MAA - Homo sapiens
input	[SimpleEntity:R-ALL-30337] HGTA [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:71077] Crystal structure of human homogentisate dioxygenase. [LiteratureReference:517446] The molecular basis of alkaptonuria [LiteratureReference:9855787] Alkaptonuria: Current Perspectives [LiteratureReference:9855784] Steady-state kinetics and inhibition of anaerobically purified human homogentisate 1,2-dioxygenase
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	HGD dioxygenates homogentisate homogentisate + O2 => 4-maleylacetoacetate + H(+) homogentisate + O2 => maleylacetoacetate
orthologousEvent	[Reaction:R-RNO-71164] HGD dioxygenates homogentisate - Rattus norvegicus [Reaction:R-DDI-71164] HGD dioxygenates homogentisate - Dictyostelium discoideum [Reaction:R-CEL-71164] HGD dioxygenates homogentisate - Caenorhabditis elegans [Reaction:R-DME-71164] HGD dioxygenates homogentisate - Drosophila melanogaster [Reaction:R-GGA-71164] HGD dioxygenates homogentisate - Gallus gallus [Reaction:R-XTR-71164] HGD dioxygenates homogentisate - Xenopus tropicalis [Reaction:R-DRE-71164] HGD dioxygenates homogentisate - Danio rerio [Reaction:R-SSC-71164] HGD dioxygenates homogentisate - Sus scrofa [Reaction:R-BTA-71164] HGD dioxygenates homogentisate - Bos taurus [Reaction:R-CFA-71164] HGD dioxygenates homogentisate - Canis familiaris [Reaction:R-MMU-71164] HGD dioxygenates homogentisate - Mus musculus
output	[SimpleEntity:R-ALL-31135] 4MAA [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[Reaction:R-HSA-71163] HPD dioxygenates HPP - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9856173] D'Eustachio, Peter, 2023-12-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-71164
summation	[Summation:178870] Cytosolic homogentisate 1,2-dioxygenase (HGD) catalyzes the ...
updateTrackers	[UpdateTracker:9791220] Update Tracker - [Reaction:71164] homogentisate + O2 => maleylacetoacetate - v32:[add_removeLiteratureReference, modifyText] [UpdateTracker:9864118] Update Tracker - [Reaction:71164] HGD dioxygenates homogentisate - v88:[addLiteratureReference, addOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9791220] Update Tracker - [Reaction:71164] homogentisate + O2 => maleylacetoacetate - v32:[add_removeLiteratureReference, modifyText] [UpdateTracker:9864118] Update Tracker - [Reaction:71164] HGD dioxygenates homogentisate - v88:[addLiteratureReference, addOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-8963684] Tyrosine catabolism
(precedingEvent)	[Reaction:R-HSA-71173] GSTZ1 isomerizes 4-MAA