Reactome | HPD dioxygenates HPP

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HPD dioxygenates HPP Show undefined attributes

catalystActivity	[CatalystActivity:9986940] 4-hydroxyphenylpyruvate dioxygenase activity of HPD:AscH-:Fe2+ dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	9986944
displayName	HPD dioxygenates HPP
eventOf	[Pathway:R-MMU-8963684] Tyrosine catabolism - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-71164] HGD dioxygenates homogentisate - Mus musculus
inferredFrom	[Reaction:R-HSA-71163] HPD dioxygenates HPP - Homo sapiens
input	[SimpleEntity:R-ALL-31365] HPP [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	HPD dioxygenates HPP 3-(4-hydroxyphenyl)pyruvate + O2 => CO2 + homogentisate p-hydroxyphenylpyruvate + O2 => homogentisate + CO2
output	[SimpleEntity:R-ALL-113528] CO2 [cytosol] [SimpleEntity:R-ALL-30337] HGTA [cytosol]
precedingEvent	[Reaction:R-MMU-71155] TAT deaminates tyrosine - Mus musculus
regulatedBy	[NegativeRegulation:9986945] Negative regulation by 'nitisinone:HPD dimer [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-71163
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8963684] Tyrosine catabolism
(precedingEvent)	[Reaction:R-MMU-71164] HGD dioxygenates homogentisate
(inferredTo)	[Reaction:R-HSA-71163] HPD dioxygenates HPP

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