Reactome | Autodegradation of the E3 ubiquitin ligase COP1

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Autodegradation of the E3 ubiquitin ligase COP1 Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10099915
displayName	Autodegradation of the E3 ubiquitin ligase COP1
eventOf	[Pathway:R-MMU-69541] Stabilization of p53 - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-349444] Phosphorylation of COP1 at Ser-387 by ATM - Mus musculus [Reaction:R-MMU-264435] Dissociation of the COP1-p53 complex - Mus musculus [Reaction:R-MMU-264418] Translocation of COP1 from the nucleus to the cytoplasm - Mus musculus [Reaction:R-MMU-264444] Autoubiquitination of phospho-COP1(Ser-387 ) - Mus musculus [BlackBoxEvent:R-MMU-264458] Proteasome mediated degradation of COP1 - Mus musculus
inferredFrom	[Pathway:R-HSA-349425] Autodegradation of the E3 ubiquitin ligase COP1 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Autodegradation of the E3 ubiquitin ligase COP1
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-349425
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-69541] Stabilization of p53
(inferredTo)	[Pathway:R-HSA-349425] Autodegradation of the E3 ubiquitin ligase COP1

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