Reactome | Regulation of TP53 Activity through Phosphorylation

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Regulation of TP53 Activity through Phosphorylation Show undefined attributes

created	[InstanceEdit:9864362] Wright, Adam, 2024-03-07
dbId	9975706
displayName	Regulation of TP53 Activity through Phosphorylation
eventOf	[Pathway:R-MMU-5633007] Regulation of TP53 Activity - Mus musculus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:3132571] regulation of signal transduction by p53 class mediator
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-MMU-5693609] ATM phosphorylates TP53 at S15 - Mus musculus [Reaction:R-MMU-6799332] ATR phosphorylates TP53 - Mus musculus [Reaction:R-MMU-69685] CHEK2 phosphorylates TP53 - Mus musculus [Reaction:R-MMU-6799246] CHEK1 phosphorylates TP53 - Mus musculus [Reaction:R-MMU-6798372] ATM phosphorylates DYRK2 - Mus musculus [Reaction:R-MMU-6798374] DYRK2 phosphorylates TP53 - Mus musculus [Reaction:R-MMU-6798373] MDM2 ubiquitinates DYRK2 - Mus musculus [Reaction:R-MMU-3215251] TP53INP1 and HIPK2 bind TP53 - Mus musculus [Reaction:R-MMU-6799409] HIPK2 phosphorylates TP53 - Mus musculus [Reaction:R-MMU-6799431] TP53 binds HIPK1 - Mus musculus [Reaction:R-MMU-6805035] TP53 binds STK11 and NUAK1 - Mus musculus [Reaction:R-MMU-3222006] STK11 (LKB1) phosphorylates NUAK1 - Mus musculus [Reaction:R-MMU-3222020] NUAK1 phosphorylates TP53 - Mus musculus [Reaction:R-MMU-6805061] CK2 binds FACT - Mus musculus [Reaction:R-MMU-6805059] CK2:FACT phosphorylates TP53 - Mus musculus [Reaction:R-MMU-6805103] AURKA phosphorylates TP53 - Mus musculus [Reaction:R-MMU-6805109] CDK2 phosphorylates TP53 - Mus musculus [Reaction:R-MMU-3222128] NOC2L binds TP53 - Mus musculus [Reaction:R-MMU-6805122] AURKB binds TP53 - Mus musculus [Reaction:R-MMU-6805126] AURKB phosphorylates TP53 - Mus musculus [Reaction:R-MMU-6805276] CDK5 phosphorylates TP53 - Mus musculus [Reaction:R-MMU-6805285] PLK3 phosphorylates TP53 - Mus musculus [Reaction:R-MMU-6805399] TAF1 phosphorylates TP53 - Mus musculus [Reaction:R-MMU-3239014] MAPKAPK5 phosphorylates TP53 - Mus musculus [Reaction:R-MMU-6805470] AMPK phosphorylates TP53 - Mus musculus [Reaction:R-MMU-6805479] TP53RK phosphorylates TP53 - Mus musculus
inferredFrom	[Pathway:R-HSA-6804756] Regulation of TP53 Activity through Phosphorylation - Homo sapiens
isInDisease	false
isInferred	true
name	Regulation of TP53 Activity through Phosphorylation
releaseDate	2024-03-27
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-6804756
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEncapsulatedEvent)	[Pathway:R-MMU-6804759] Regulation of TP53 Activity through Association with Co-factors [Pathway:R-MMU-6806003] Regulation of TP53 Expression and Degradation
(hasEvent)	[Pathway:R-MMU-5633007] Regulation of TP53 Activity
(inferredTo)	[Pathway:R-HSA-6804756] Regulation of TP53 Activity through Phosphorylation

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