Reactome | JAK1 binds IL4R in IL4-bound IL4R1

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JAK1 binds IL4R in IL4-bound IL4R1 Show undefined attributes

category	omitted
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10065821
displayName	JAK1 binds IL4R in IL4-bound IL4R1
eventOf	[Pathway:R-MMU-6785807] Interleukin-4 and Interleukin-13 signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-MMU-6786096] IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated - Mus musculus
inferredFrom	[BlackBoxEvent:R-HSA-6786058] JAK1 binds IL4R in IL4-bound IL4R1 - Homo sapiens
input	[Complex:R-MMU-6786078] IL4:IL4R:JAK2:IL2RG:JAK3 [plasma membrane] [EntityWithAccessionedSequence:R-MMU-451898] JAK1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	JAK1 binds IL4R in IL4-bound IL4R1
output	[Complex:R-MMU-6786090] IL4:IL4R:JAK2:IL2RG:JAK3:JAK1 [plasma membrane]
precedingEvent	[Reaction:R-MMU-6786092] IL4:IL4R:JAK2 binds IL2RG:JAK3 - Mus musculus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-6786058
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-6785807] Interleukin-4 and Interleukin-13 signaling
(precedingEvent)	[BlackBoxEvent:R-MMU-6786096] IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated
(inferredTo)	[BlackBoxEvent:R-HSA-6786058] JAK1 binds IL4R in IL4-bound IL4R1

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