Reactome | IL2RG binds JAK3

Schema > Reaction > Entries

IL2RG binds JAK3 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10019152
displayName	IL2RG binds JAK3
eventOf	[Pathway:R-MMU-8985947] Interleukin-9 signaling - Mus musculus [Pathway:R-MMU-6785807] Interleukin-4 and Interleukin-13 signaling - Mus musculus [Pathway:R-MMU-9020558] Interleukin-2 signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-449958] IL7:IL7R:JAK1 binds IL2RG:JAK3 - Mus musculus [BlackBoxEvent:R-MMU-9006844] IL21:IL21R:JAK1 binds IL2RG:JAK3 - Mus musculus [BlackBoxEvent:R-MMU-8983298] IL15 binds IL2RB:JAK1 and IL2RG:JAK3 - Mus musculus [Reaction:R-MMU-8963734] IL9 binds IL9R:JAK1 and IL2RG:JAK3 - Mus musculus [Reaction:R-MMU-6786092] IL4:IL4R:JAK2 binds IL2RG:JAK3 - Mus musculus [Reaction:R-MMU-450063] Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit - Mus musculus [BlackBoxEvent:R-MMU-449115] IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 - Mus musculus
inferredFrom	[Reaction:R-HSA-451895] IL2RG binds JAK3 - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-539020] Il2rg [plasma membrane] [EntityWithAccessionedSequence:R-MMU-451893] JAK3 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	IL2RG binds JAK3
output	[Complex:R-MMU-451911] IL2RG:JAK3 [plasma membrane]
regulatedBy	[NegativeRegulation:10019153] Negative regulation by 'JAK3:JAK3 inhibitors [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-451895
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-6785807] Interleukin-4 and Interleukin-13 signaling [Pathway:R-MMU-1266695] Interleukin-7 signaling [Pathway:R-MMU-9020558] Interleukin-2 signaling [Pathway:R-MMU-8985947] Interleukin-9 signaling
(precedingEvent)	[BlackBoxEvent:R-MMU-9006844] IL21:IL21R:JAK1 binds IL2RG:JAK3 [Reaction:R-MMU-449958] IL7:IL7R:JAK1 binds IL2RG:JAK3 [BlackBoxEvent:R-MMU-8983298] IL15 binds IL2RB:JAK1 and IL2RG:JAK3 [BlackBoxEvent:R-MMU-449115] IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 [Reaction:R-MMU-8963734] IL9 binds IL9R:JAK1 and IL2RG:JAK3 [Reaction:R-MMU-6786092] IL4:IL4R:JAK2 binds IL2RG:JAK3 [Reaction:R-MMU-450063] Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit
(inferredTo)	[Reaction:R-HSA-451895] IL2RG binds JAK3

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