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Schema
>
BlackBoxEvent
>
Entries
NoRC:intergenic spacer:Hdac:Dnmt complex deacetylates histone H4 and dimethylates lysine-9 of histone H3 in main promoter of the rRNA gene
Show undefined attributes
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authored
[InstanceEdit:565730] May, B, 2010-04-06
catalystActivity
[CatalystActivity:573375] histone deacetylase activity of NoRC:pRNA:Hdac:Dnmt [nucleoplasm]
category
omitted
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:573322] May, B, 2010-04-10
dbId
573376
deleted
[Deleted:9032446] Deletion of instance: 573389
[Deleted:9032440] Deletion of instance: 5334727
displayName
NoRC:intergenic spacer:Hdac:Dnmt complex deacetylates histone H4 and dimethylates lysine-9 of histone H3 in main promoter of the rRNA gene
edited
[InstanceEdit:565730] May, B, 2010-04-06
followingEvent
[Reaction:R-MMU-573383] NoRC:intergenic spacer:Hdac:Dnmt complex methylates cytosine in the rRNA genes - Mus musculus
input
4 ×
[SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm]
[Complex:R-MMU-573317] Nucleosome (H4K5ac, H4K8ac, H4K16ac) [nucleoplasm]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:427357] Epigenetic mechanism of rRNA gene silencing: temporal order of NoRC-mediated histone modification, chromatin remodeling, and DNA methylation
[LiteratureReference:427396] The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription
[LiteratureReference:427450] The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing
[LiteratureReference:427384] The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription
maxDepth
1
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
NoRC:intergenic spacer:Hdac:Dnmt complex deacetylates histone H4 and dimethylates lysine-9 of histone H3 in main promoter of the rRNA gene
orthologousEvent
[BlackBoxEvent:R-HSA-433672] NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3 - Homo sapiens
output
4 ×
[SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm]
6 ×
[SimpleEntity:R-ALL-427486] CH3COO- [nucleoplasm]
[Complex:R-MMU-573397] Nucleosome (deacetylated H4, H3K9me2) [nucleoplasm]
precedingEvent
[Reaction:R-MMU-573336] Nucleolar Chromatin Remodeling Complex (NoRC) binds intergenic spacer of rRNA gene - Mus musculus
releaseDate
2014-03-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5332991] Shiao, YH, 2014-02-18
schemaClass
BlackBoxEvent
species
[Species:48892] Mus musculus
stId
R-MMU-573376
summation
[Summation:580601] Histones in silenced rRNA gene copies are deacetylated by Hd...
Referrals
(replacementInstances)
[Deleted:9032440] Deletion of instance: 5334727
[Deleted:9032446] Deletion of instance: 573389
(precedingEvent)
[Reaction:R-MMU-573383] NoRC:intergenic spacer:Hdac:Dnmt complex methylates cytosine in the rRNA genes
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