Reactome | Nucleolar Chromatin Remodeling Complex (NoRC) binds intergenic spacer of rRNA gene

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Nucleolar Chromatin Remodeling Complex (NoRC) binds intergenic spacer of rRNA gene Show undefined attributes

authored	[InstanceEdit:565730] May, B, 2010-04-06
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:573322] May, B, 2010-04-10
dbId	573336
deleted	[Deleted:9032446] Deletion of instance: 573389 [Deleted:9032440] Deletion of instance: 5334727
displayName	Nucleolar Chromatin Remodeling Complex (NoRC) binds intergenic spacer of rRNA gene
edited	[InstanceEdit:565730] May, B, 2010-04-06
followingEvent	[BlackBoxEvent:R-MMU-573376] NoRC:intergenic spacer:Hdac:Dnmt complex deacetylates histone H4 and dimethylates lysine-9 of histone H3 in main promoter of the rRNA gene - Mus musculus
input	[EntityWithAccessionedSequence:R-MMU-573310] Dnmt1 [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-5096479] Dnmt3b [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-573340] Hdac1 [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-573366] Hdac2 [nucleoplasm] [Complex:R-MMU-573354] NoRC [nucleoplasm] [GenomeEncodedEntity:R-MMU-9034641] pRNA from rDNA (intergenic rRNA) [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-573325] Rbbp4 [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-573353] Rbbp7 [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-573349] Sap18 [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-573342] Sap30 [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-573326] Sin3a [nucleoplasm] [Complex:R-MMU-573309] Ttf-I:T0 region of rDNA [nucleoplasm]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:427396] The nucleolar remodeling complex NoRC mediates heterochromatin formation and silencing of ribosomal gene transcription [LiteratureReference:427450] The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing [LiteratureReference:427357] Epigenetic mechanism of rRNA gene silencing: temporal order of NoRC-mediated histone modification, chromatin remodeling, and DNA methylation [LiteratureReference:5096481] Interaction of noncoding RNA with the rDNA promoter mediates recruitment of DNMT3b and silencing of rRNA genes [LiteratureReference:5084145] Intergenic transcripts originating from a subclass of ribosomal DNA repeats silence ribosomal RNA genes in trans [LiteratureReference:427411] Intergenic transcripts regulate the epigenetic state of rRNA genes [LiteratureReference:573332] NoRC--a novel member of mammalian ISWI-containing chromatin remodeling machines [LiteratureReference:5219066] The chromatin remodeling complex NoRC and TTF-I cooperate in the regulation of the mammalian rRNA genes in vivo [LiteratureReference:5219065] Recruitment of the nucleolar remodeling complex NoRC establishes ribosomal DNA silencing in chromatin
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Nucleolar Chromatin Remodeling Complex (NoRC) binds intergenic spacer of rRNA gene
orthologousEvent	[Reaction:R-HSA-427409] Nucleolar Remodelling Complex (NoRC) binds intergenic region of rDNA - Homo sapiens
output	[Complex:R-MMU-573319] NoRC:pRNA:Hdac:Dnmt [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-573306] Ttf1 [nucleoplasm]
precedingEvent	[Reaction:R-MMU-573369] Ttf-I binds the T0 region (Sal Box) of the rDNA - Mus musculus
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5332991] Shiao, YH, 2014-02-18
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-573336
summation	[Summation:580596] The Nucleolar Remodeling Complex (NoRC) comprises Tip5 (Baz2...
updateTrackers	[UpdateTracker:9780038] Update Tracker - [Reaction:573336] Nucleolar Chromatin Remodeling Complex (NoRC) binds intergenic spacer of rRNA gene - v64:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9780038] Update Tracker - [Reaction:573336] Nucleolar Chromatin Remodeling Complex (NoRC) binds intergenic spacer of rRNA gene - v64:[add_removeInput]
(replacementInstances)	[Deleted:9032440] Deletion of instance: 5334727 [Deleted:9032446] Deletion of instance: 573389
(precedingEvent)	[BlackBoxEvent:R-MMU-573376] NoRC:intergenic spacer:Hdac:Dnmt complex deacetylates histone H4 and dimethylates lysine-9 of histone H3 in main promoter of the rRNA gene

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