Reactome | RHO GTPases Activate NADPH Oxidases

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RHO GTPases Activate NADPH Oxidases Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane [Compartment:1222693] phagocytic vesicle membrane [Compartment:263698] phagolysosome
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10101101
displayName	RHO GTPases Activate NADPH Oxidases
eventOf	[Pathway:R-MMU-195258] RHO GTPase Effectors - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-MMU-5218827] NADPH oxidase 2 (NOX2) complex binds RAC1 - Mus musculus [Reaction:R-MMU-5218841] NADPH oxidase 2 generates superoxide from oxygen - Mus musculus [Reaction:R-MMU-5668605] RAC2:GTP binds NOX2 complex - Mus musculus [Reaction:R-MMU-5668629] Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP - Mus musculus [Reaction:R-MMU-5668714] RAC1:GTP binds NOX1 complex - Mus musculus [Reaction:R-MMU-5668718] NOX1 complex:RAC1:GTP generates superoxide from oxygen - Mus musculus [Reaction:R-MMU-5668735] RAC1:GTP binds NOX3 complex - Mus musculus [Reaction:R-MMU-5668731] NOX3 complex:RAC1:GTP generates superoxide from oxygen - Mus musculus [Reaction:R-MMU-6798174] PIK3C3:PIK3R4 phosphorylates PI to PI3P - Mus musculus [Reaction:R-MMU-9626832] MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 - Mus musculus [Reaction:R-MMU-9626880] MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 - Mus musculus [Reaction:R-MMU-9626816] PIN1 binds p-S345-NCF1 - Mus musculus [Reaction:R-MMU-9626817] PKC phosphorylates NCF1 - Mus musculus [Reaction:R-MMU-9626848] S100A8:S100A9:AA:Ca(2+) binds NOX2 complex - Mus musculus
inferredFrom	[Pathway:R-HSA-5668599] RHO GTPases Activate NADPH Oxidases - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	RHO GTPases Activate NADPH Oxidases
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-5668599
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-195258] RHO GTPase Effectors
(hasEncapsulatedEvent)	[Pathway:R-MMU-1222556] ROS and RNS production in phagocytes
(inferredTo)	[Pathway:R-HSA-5668599] RHO GTPases Activate NADPH Oxidases

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