Reactome | MAPK11 or MAPK14 phosphorylates NCF1 at Ser345

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MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 Show undefined attributes

catalystActivity	[CatalystActivity:451186] protein serine/threonine kinase activity of phospho-MAPK p38 alpha/beta [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10088214
displayName	MAPK11 or MAPK14 phosphorylates NCF1 at Ser345
eventOf	[Pathway:R-MMU-5668599] RHO GTPases Activate NADPH Oxidases - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-9626816] PIN1 binds p-S345-NCF1 - Mus musculus
inferredFrom	[Reaction:R-HSA-9626880] MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-9626870] NCF1:NCF2:NCF4 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 p38 MAPK phosphorylates NCF1 at Ser345
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-9626850] p-S-345-NCF1:NCF2:NCF4 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9626880
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5668599] RHO GTPases Activate NADPH Oxidases
(precedingEvent)	[Reaction:R-MMU-9626816] PIN1 binds p-S345-NCF1
(inferredTo)	[Reaction:R-HSA-9626880] MAPK11 or MAPK14 phosphorylates NCF1 at Ser345

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