Reactome | S100A8:S100A9:AA:Ca(2+) binds NOX2 complex

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S100A8:S100A9:AA:Ca(2+) binds NOX2 complex Show undefined attributes

category	binding
compartment	[Compartment:1222693] phagocytic vesicle membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10088212
displayName	S100A8:S100A9:AA:Ca(2+) binds NOX2 complex
eventOf	[Pathway:R-MMU-5668599] RHO GTPases Activate NADPH Oxidases - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9626848] S100A8:S100A9:AA:Ca(2+) binds NOX2 complex - Homo sapiens
input	[Complex:R-MMU-5668618] NOX2 complex:RAC2:GTP [phagocytic vesicle membrane] [Complex:R-MMU-9626862] S100A8:S100A9:AA:Ca2+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	S100A8:S100A9:AA:Ca(2+) binds NOX2 complex Calprotectin heterotetramer binds NOX2 complex
output	[Complex:R-MMU-9626792] NOX2 complex:S100A8:S100A9:Ca2+ [phagocytic vesicle membrane]
precedingEvent	[Reaction:R-MMU-5668605] RAC2:GTP binds NOX2 complex - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9626848
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5668599] RHO GTPases Activate NADPH Oxidases
(inferredTo)	[Reaction:R-HSA-9626848] S100A8:S100A9:AA:Ca(2+) binds NOX2 complex

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