Reactome | Retinoic acid activates Hoxb1 chromatin

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Retinoic acid activates Hoxb1 chromatin Show undefined attributes

authored	[InstanceEdit:5617898] May, Bruce, 2014-08-15 [InstanceEdit:6810137] Rezsohazy, Ren�, 2015-11-15
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5617923] May, Bruce, 2014-08-16
dbId	5617960
displayName	Retinoic acid activates Hoxb1 chromatin
edited	[InstanceEdit:5617898] May, Bruce, 2014-08-15
followingEvent	[BlackBoxEvent:R-MMU-5693628] Hoxb1 maintains activation of Hoxb1 chromatin - Mus musculus [BlackBoxEvent:R-MMU-5617972] Hoxb1 gene is transcribed - Mus musculus
input	[SimpleEntity:R-ALL-5334804] atRA [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-556805] Ep300 [nucleoplasm] [Complex:R-MMU-5619354] Mll2,3 complex [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-556815] Ncoa3 [nucleoplasm] [Complex:R-MMU-5617903] Rara,g:Rxra at Hoxb1 bivalent chromatin [nucleoplasm] [Complex:R-MMU-216411] RNA polymerase II holoenzyme (generic) [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5618003] Hox cluster polarity in early transcriptional availability: a high order regulatory level of clustered Hox genes in the mouse [LiteratureReference:5617910] Roles of retinoic acid receptors in early embryonic morphogenesis and hindbrain patterning [LiteratureReference:5617966] Distinct retinoid X receptor-retinoic acid receptor heterodimers are differentially involved in the control of expression of retinoid target genes in F9 embryonal carcinoma cells [LiteratureReference:5617936] Retinoic acid-responsive enhancers located 3' of the Hox A and Hox B homeobox gene clusters. Functional analysis [LiteratureReference:5617967] Evidence for two distinct retinoic acid response pathways for HOXB1 gene regulation [LiteratureReference:5617933] A retinoic acid-triggered cascade of HOXB1 gene activation [LiteratureReference:5617968] Analysis of two distinct retinoic acid response elements in the homeobox gene Hoxb1 in transgenic mice [LiteratureReference:5617918] Functional dissection of a transcriptionally active, target-specific Hox-Pbx complex [LiteratureReference:5619290] Role of a conserved retinoic acid response element in rhombomere restriction of Hoxb-1 [LiteratureReference:5619198] A conserved retinoic acid response element required for early expression of the homeobox gene Hoxb-1 [LiteratureReference:5675616] Expression of Hoxb genes in the developing mouse foregut and lung [LiteratureReference:5675602] Segment-specific expression of a homoeobox-containing gene in the mouse hindbrain [LiteratureReference:5675609] Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain [LiteratureReference:5675605] Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors [LiteratureReference:5617993] Epigenomic reorganization of the clustered Hox genes in embryonic stem cells induced by retinoic acid [LiteratureReference:5688606] Genetic interactions between Hoxa1 and Hoxb1 reveal new roles in regulation of early hindbrain patterning [LiteratureReference:5688598] Hoxa1 and Hoxb1 synergize in patterning the hindbrain, cranial nerves and second pharyngeal arch [LiteratureReference:5688580] Hoxb1 neural crest preferentially form glia of the PNS [LiteratureReference:5618004] Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals [LiteratureReference:5617928] Retinoid regulated association of transcriptional co-regulators and the polycomb group protein SUZ12 with the retinoic acid response elements of Hoxa1, RARbeta(2), and Cyp26A1 in F9 embryonal carcinoma cells [LiteratureReference:5617912] Epigenetic regulatory mechanisms distinguish retinoic acid-mediated transcriptional responses in stem cells and fibroblasts [LiteratureReference:5690634] Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II [LiteratureReference:5693640] Hoxb1 enhancer and control of rhombomere 4 expression: complex interplay between PREP1-PBX1-HOXB1 binding sites
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Retinoic acid activates Hoxb1 chromatin
orthologousEvent	[BlackBoxEvent:R-HSA-5617452] Retinoic acid activates HOXB1 chromatin - Homo sapiens
output	[Complex:R-MMU-5617983] atRA:Rara,g:Rxra at active Hoxb1 chromatin [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-442459] Ncor1 [nucleoplasm] [Complex:R-MMU-5617945] PRC2 (EZH2) [nucleoplasm]
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693642] Blasi, F, 2015-05-13
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-5617960
summation	[Summation:5617911] In mouse embryos (Marshall et al. 1994, Studer et al. 1994, ...

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