Reactome | CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments

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CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments Show undefined attributes

catalystActivity	[CatalystActivity:9998617] cyclin-dependent protein serine/threonine kinase activity of CCNB1:p-T161-CDK1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10053413
displayName	CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments
eventOf	[Pathway:R-MMU-4419969] Depolymerization of the Nuclear Lamina - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5244669] CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [CandidateSet:R-MMU-5229191] p-S395-Lamin dimers [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [CandidateSet:R-MMU-5244666] p-S22/23, S395-Lamin dimers [nucleoplasm]
precedingEvent	[Depolymerisation:R-MMU-5229194] Depolymerization of lamin filaments after PKC-mediated phosphorylation - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5244669
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-4419969] Depolymerization of the Nuclear Lamina
(inferredTo)	[Reaction:R-HSA-5244669] CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments

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