Reactome | CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments

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CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments Show undefined attributes

authored	[InstanceEdit:5251380] Orlic-Milacic, M, 2014-02-02
catalystActivity	[CatalystActivity:174240] cyclin-dependent protein serine/threonine kinase activity of CCNB1:p-T161-CDK1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5244668] Orlic-Milacic, M, 2014-01-20
dbId	5244669
displayName	CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments
edited	[InstanceEdit:5251380] Orlic-Milacic, M, 2014-02-02
eventOf	[Pathway:R-HSA-4419969] Depolymerization of the Nuclear Lamina - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [CandidateSet:R-HSA-5229191] p-S395-Lamin dimers [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5244673] Identification of cell cycle-regulated phosphorylation sites on nuclear lamin C [LiteratureReference:5244680] In vitro disassembly of the nuclear lamina and M phase-specific phosphorylation of lamins by cdc2 kinase [LiteratureReference:5244681] Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis [LiteratureReference:4419965] Mitotic lamin disassembly is triggered by lipid-mediated signaling
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments
orthologousEvent	[Reaction:R-BTA-5244669] CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments - Bos taurus [Reaction:R-CEL-5244669] CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments - Caenorhabditis elegans [Reaction:R-DME-5244669] CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments - Drosophila melanogaster [Reaction:R-XTR-5244669] CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments - Xenopus tropicalis [Reaction:R-DRE-5244669] CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments - Danio rerio [Reaction:R-SSC-5244669] CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments - Sus scrofa [Reaction:R-CFA-5244669] CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments - Canis familiaris [Reaction:R-RNO-5244669] CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments - Rattus norvegicus [Reaction:R-MMU-5244669] CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [CandidateSet:R-HSA-5244666] p-S22/23, S395-Lamin dimers [nucleoplasm]
precedingEvent	[Depolymerisation:R-HSA-5229194] Depolymerization of lamin filaments after PKC-mediated phosphorylation - Homo sapiens
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5324613] Gorj�n�cz, M�ty�s, 2014-02-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5244669
summation	[Summation:5244776] Phosphorylation of the N-termini of lamins by CDK1 (serine S...

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(hasEvent)

[Pathway:R-HSA-4419969] Depolymerization of the Nuclear Lamina