Reactome | Depolymerization of the Nuclear Lamina

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Depolymerization of the Nuclear Lamina Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10101067
displayName	Depolymerization of the Nuclear Lamina
eventOf	[Pathway:R-MMU-2980766] Nuclear Envelope Breakdown - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-5195402] CDK1 phosphorylates LPIN - Mus musculus [Reaction:R-MMU-4419948] CTDNEP1:CNEP1R1 dephosphorylates LPIN - Mus musculus [Reaction:R-MMU-5221130] LPIN catalyzes conversion of phosphatidic acid to diacylglycerol - Mus musculus [Reaction:R-MMU-5223304] DAG and Ca+2 bind to PKC and tether it to membrane - Mus musculus [Depolymerisation:R-MMU-5229194] Depolymerization of lamin filaments after PKC-mediated phosphorylation - Mus musculus [Reaction:R-MMU-5244669] CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments - Mus musculus
inferredFrom	[Pathway:R-HSA-4419969] Depolymerization of the Nuclear Lamina - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Depolymerization of the Nuclear Lamina
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-4419969
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-2980766] Nuclear Envelope Breakdown
(inferredTo)	[Pathway:R-HSA-4419969] Depolymerization of the Nuclear Lamina

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