Reactome | Phosphorylation of nephrin by FYN

Schema > Reaction > Entries

Phosphorylation of nephrin by FYN Show undefined attributes

catalystActivity	[CatalystActivity:10008774] protein tyrosine kinase activity of NPHS1 dimer:KIRREL:FYN [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10008776
displayName	Phosphorylation of nephrin by FYN
eventOf	[Pathway:R-MMU-373753] Nephrin family interactions - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-373724] Nephrin binds NCK - Mus musculus [Reaction:R-MMU-373734] Nephrin interacts with Podocin - Mus musculus
inferredFrom	[Reaction:R-HSA-373747] Phosphorylation of nephrin by FYN - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-8981533] NPHS1 dimer:KIRREL:FYN [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of nephrin by FYN
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-374555] p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane]
precedingEvent	[Reaction:R-MMU-8981534] Nephrin dimer:KIRREL binds FYN - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-373747
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-373753] Nephrin family interactions
(precedingEvent)	[Reaction:R-MMU-373724] Nephrin binds NCK [Reaction:R-MMU-373734] Nephrin interacts with Podocin
(inferredTo)	[Reaction:R-HSA-373747] Phosphorylation of nephrin by FYN

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