Reactome | Phosphorylation of nephrin by FYN

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Phosphorylation of nephrin by FYN Show undefined attributes

authored	[InstanceEdit:214881] de Bono, B, Garapati, P V, 2008-02-26 12:30:30
catalystActivity	[CatalystActivity:374399] protein tyrosine kinase activity of NPHS1 dimer:KIRREL:FYN [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:373742] Garapati, P V, 2008-07-16 14:41:39
dbId	373747
displayName	Phosphorylation of nephrin by FYN
edited	[InstanceEdit:532602] Garapati, P V, 2010-03-01
eventOf	[Pathway:R-HSA-373753] Nephrin family interactions - Homo sapiens
followingEvent	[Reaction:R-HSA-373724] Nephrin binds NCK - Homo sapiens [Reaction:R-HSA-373727] Nephrin binds CD2AP - Homo sapiens [Reaction:R-HSA-373734] Nephrin interacts with Podocin - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-8981533] NPHS1 dimer:KIRREL:FYN [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:654765] Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization [LiteratureReference:373517] Clustering-induced tyrosine phosphorylation of nephrin by Src family kinases [LiteratureReference:654761] Fyn binds to and phosphorylates the kidney slit diaphragm component Nephrin [LiteratureReference:374484] SRC-family kinase Fyn phosphorylates the cytoplasmic domain of nephrin and modulates its interaction with podocin [LiteratureReference:451752] Nephrin mediates actin reorganization via phosphoinositide 3-kinase in podocytes
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Phosphorylation of nephrin by FYN
orthologousEvent	[Reaction:R-CEL-373747] Phosphorylation of nephrin by FYN - Caenorhabditis elegans [Reaction:R-DRE-373747] Phosphorylation of nephrin by FYN - Danio rerio [Reaction:R-SSC-373747] Phosphorylation of nephrin by FYN - Sus scrofa [Reaction:R-BTA-373747] Phosphorylation of nephrin by FYN - Bos taurus [Reaction:R-CFA-373747] Phosphorylation of nephrin by FYN - Canis familiaris [Reaction:R-RNO-373747] Phosphorylation of nephrin by FYN - Rattus norvegicus [Reaction:R-MMU-373747] Phosphorylation of nephrin by FYN - Mus musculus
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-374555] p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane]
precedingEvent	[Reaction:R-HSA-8981534] Nephrin dimer:KIRREL binds FYN - Homo sapiens
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:765028] Huber, TB, Grahammer, Florian, 2010-05-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-373747
summation	[Summation:373602] Nephrin has eight putative phosphorylation sites, which nice...
updateTrackers	[UpdateTracker:9781448] Update Tracker - [Reaction:373747] Phosphorylation of nephrin by FYN - v61:[add_removeInput]

Referrals

(updatedInstance)	[UpdateTracker:9781448] Update Tracker - [Reaction:373747] Phosphorylation of nephrin by FYN - v61:[add_removeInput]
(hasEvent)	[Pathway:R-HSA-373753] Nephrin family interactions
(precedingEvent)	[Reaction:R-HSA-373724] Nephrin binds NCK [Reaction:R-HSA-373727] Nephrin binds CD2AP [Reaction:R-HSA-373734] Nephrin interacts with Podocin

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