Reactome | Nephrin dimer:KIRREL binds FYN

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Nephrin dimer:KIRREL binds FYN Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10084424
displayName	Nephrin dimer:KIRREL binds FYN
eventOf	[Pathway:R-MMU-373753] Nephrin family interactions - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-373747] Phosphorylation of nephrin by FYN - Mus musculus
inferredFrom	[Reaction:R-HSA-8981534] Nephrin dimer:KIRREL binds FYN - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-420333] Fyn [cytosol] [Complex:R-MMU-373679] NPHS1 dimer:KIRREL [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Nephrin dimer:KIRREL binds FYN
output	[Complex:R-MMU-8981533] NPHS1 dimer:KIRREL:FYN [plasma membrane]
precedingEvent	[Reaction:R-MMU-373714] Cis-Heterodimerization of nephrin and KIRREL - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-8981534
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-373753] Nephrin family interactions
(precedingEvent)	[Reaction:R-MMU-373747] Phosphorylation of nephrin by FYN
(inferredTo)	[Reaction:R-HSA-8981534] Nephrin dimer:KIRREL binds FYN

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