Reactome | Autodegradation of the E3 ubiquitin ligase COP1

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Autodegradation of the E3 ubiquitin ligase COP1 Show undefined attributes

authored	[InstanceEdit:353601] Matthews, L, 2008-06-12 21:09:06
created	[InstanceEdit:349466] Matthews, L, 2008-05-07 22:49:21
crossReference	[DatabaseIdentifier:12819593] BioModels Database:BIOMD0000000634
dbId	349425
displayName	Autodegradation of the E3 ubiquitin ligase COP1
edited	[InstanceEdit:446058] Matthews, L, 2009-11-09
eventOf	[Pathway:R-HSA-69541] Stabilization of p53 - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-349444] Phosphorylation of COP1 at Ser-387 by ATM - Homo sapiens [Reaction:R-HSA-264435] Dissociation of the COP1-p53 complex - Homo sapiens [Reaction:R-HSA-264418] Translocation of COP1 from the nucleus to the cytoplasm - Homo sapiens [Reaction:R-HSA-264444] Autoubiquitination of phospho-COP1(Ser-387 ) - Homo sapiens [BlackBoxEvent:R-HSA-264458] Proteasome mediated degradation of COP1 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2015-09-30
literatureReference	[LiteratureReference:349437] ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Autodegradation of the E3 ubiquitin ligase COP1
orthologousEvent	[Pathway:R-DDI-349425] Autodegradation of the E3 ubiquitin ligase COP1 - Dictyostelium discoideum [Pathway:R-GGA-349425] Autodegradation of the E3 ubiquitin ligase COP1 - Gallus gallus [Pathway:R-XTR-349425] Autodegradation of the E3 ubiquitin ligase COP1 - Xenopus tropicalis [Pathway:R-DRE-349425] Autodegradation of the E3 ubiquitin ligase COP1 - Danio rerio [Pathway:R-SSC-349425] Autodegradation of the E3 ubiquitin ligase COP1 - Sus scrofa [Pathway:R-BTA-349425] Autodegradation of the E3 ubiquitin ligase COP1 - Bos taurus [Pathway:R-CFA-349425] Autodegradation of the E3 ubiquitin ligase COP1 - Canis familiaris [Pathway:R-RNO-349425] Autodegradation of the E3 ubiquitin ligase COP1 - Rattus norvegicus [Pathway:R-MMU-349425] Autodegradation of the E3 ubiquitin ligase COP1 - Mus musculus
releaseDate	2009-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:446711] Dixit, VM, 2009-11-17
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-349425
summation	[Summation:349475] COP1 is one of several E3 ubiquitin ligases responsible for...
updateTrackers	[UpdateTracker:9791143] Update Tracker - [Pathway:349425] Autodegradation of the E3 ubiquitin ligase COP1 - v32:[updateContainedRLE] [UpdateTracker:9784532] Update Tracker - [Pathway:349425] Autodegradation of the E3 ubiquitin ligase COP1 - v54:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9791143] Update Tracker - [Pathway:349425] Autodegradation of the E3 ubiquitin ligase COP1 - v32:[updateContainedRLE] [UpdateTracker:9784532] Update Tracker - [Pathway:349425] Autodegradation of the E3 ubiquitin ligase COP1 - v54:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-69541] Stabilization of p53