Reactome | Deletion of instance: 2586551

Schema > Deleted > Entries

Deletion of instance: 2586551 Show undefined attributes

created	[InstanceEdit:9032449] May, Bruce, 2017-12-12
curatorComment	The deleted pathway was a manually curated mouse pathway whose reactions were used only for inference of human reactions. The reactions contained in the deleted pathway are listed in replacementInstances.
dbId	9032439
deletedInstance	[DeletedInstance:9747318] Deleted Instance - [Pathway: Signaling by Leptin (2586551) - [Species:48892] Mus musculus]
deletedInstanceDbId	2586551
displayName	Deletion of instance: 2586551
modified	[InstanceEdit:9851216] Wu, Guanming, 2023-10-14
reason	[DeletedControlledVocabulary:188249] Obsoleted
replacementInstances	[Reaction:R-MMU-2586558] Leptin Binds Leptin Receptor - Mus musculus [Reaction:R-MMU-2586548] Jak2 Autophosphorylates in Response to Leptin - Mus musculus [Reaction:R-MMU-2586557] Jak2 Phosphorylates Lepr - Mus musculus [Reaction:R-MMU-2671739] Phosphorylated Lepr Binds Shp2 - Mus musculus [Reaction:R-MMU-2671740] Jak2 Phosphorylates Shp2 in Response to Leptin - Mus musculus [Reaction:R-MMU-2671831] Phosphorylated Lepr Binds Stat5 - Mus musculus [Reaction:R-MMU-2671843] Jak2 Phosphorylates Stat5 in Response to Leptin - Mus musculus [Reaction:R-MMU-2671832] Phosphorylated Stat5 Dissociates from Leptin Receptor - Mus musculus [Reaction:R-MMU-2730593] Phosphorylated Stat5 dimerizes - Mus musculus [BlackBoxEvent:R-MMU-2730596] Phosphorylated Stat5 Dimer Translocates to the Nucleus - Mus musculus [Reaction:R-MMU-2671854] Phosphorylated Lepr Binds Stat3 - Mus musculus [Reaction:R-MMU-2671836] Jak2 Phosphorylates Stat3 in Response to Leptin - Mus musculus [Reaction:R-MMU-2671877] Phosphorylated Stat3 Dissociates from Leptin Receptor - Mus musculus [Reaction:R-MMU-2730597] Phosphorylated Stat3 Forms Dimer - Mus musculus [BlackBoxEvent:R-MMU-2730598] Phosphorylated Stat3 Dimer Translocates to the Nucleus - Mus musculus [Reaction:R-MMU-2671852] Phosphoryated Lep:Lepr:Jak2 Binds Sh2b1 - Mus musculus [Reaction:R-MMU-2671841] Phosphorylated Lep:Lepr:Jak2:Sh2b1 Binds Irs1/2 - Mus musculus [Reaction:R-MMU-2671830] Jak2 Phosphorylates Irs1/2 in Response to Leptin - Mus musculus [Reaction:R-MMU-2672295] Phosphorylated Lepr Binds Socs3 - Mus musculus
schemaClass	Deleted