Reactome | Jak2 Phosphorylates Lepr

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Jak2 Phosphorylates Lepr Show undefined attributes

authored	[InstanceEdit:2586547] May, B, 2012-11-15
catalystActivity	[CatalystActivity:2586556] protein tyrosine kinase activity of Lep:Lepr:p-Jak2 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2586547] May, B, 2012-11-15
dbId	2586557
deleted	[Deleted:9032439] Deletion of instance: 2586551 [Deleted:9032440] Deletion of instance: 5334727
displayName	Jak2 Phosphorylates Lepr
edited	[InstanceEdit:2671737] May, B, 2012-11-24
followingEvent	[Reaction:R-MMU-2671739] Phosphorylated Lepr Binds Shp2 - Mus musculus [Reaction:R-MMU-2671852] Phosphoryated Lep:Lepr:Jak2 Binds Sh2b1 - Mus musculus [Reaction:R-MMU-2672295] Phosphorylated Lepr Binds Socs3 - Mus musculus [Reaction:R-MMU-2671831] Phosphorylated Lepr Binds Stat5 - Mus musculus [Reaction:R-MMU-2671854] Phosphorylated Lepr Binds Stat3 - Mus musculus
input	6 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-2586535] Lep:Lepr:p-Jak2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2586489] Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor [LiteratureReference:2586463] Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Jak2 Phosphorylates Lepr
orthologousEvent	[Reaction:R-HSA-2586553] JAK2 Phosphorylates LEPR - Homo sapiens
output	6 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-2586540] Lep:p-Lepr:p-Jak2 [plasma membrane]
precedingEvent	[Reaction:R-MMU-2586548] Jak2 Autophosphorylates in Response to Leptin - Mus musculus
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4420239] Scherer, Thomas, 2013-08-31 [InstanceEdit:4789050] Gonzalez-Perez, Ruben Rene, 2013-10-26
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-2586557
summation	[Summation:2672294] Jak2 phosphorylates Lepr at multiple tyrosine residues, incl...

Referrals

(replacementInstances)	[Deleted:9032439] Deletion of instance: 2586551 [Deleted:9032440] Deletion of instance: 5334727
(precedingEvent)	[Reaction:R-MMU-2671739] Phosphorylated Lepr Binds Shp2 [Reaction:R-MMU-2671852] Phosphoryated Lep:Lepr:Jak2 Binds Sh2b1 [Reaction:R-MMU-2672295] Phosphorylated Lepr Binds Socs3 [Reaction:R-MMU-2671831] Phosphorylated Lepr Binds Stat5 [Reaction:R-MMU-2671854] Phosphorylated Lepr Binds Stat3