Jak2 Phosphorylates Lepr

Stable Identifier
R-MMU-2586557
Type
Reaction [transition]
Species
Mus musculus
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Jak2 Phosphorylates Lepr
Jak2 phosphorylates Lepr at multiple tyrosine residues, including at least Tyr-985, Tyr-1077, and Tyr-1138.
Literature References
PubMed ID Title Journal Year
11108838 Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor

Eyckerman, S, Broekaert, D, Verhee, A, Vandekerckhove, J, Tavernier, J

FEBS Lett. 2000
10449753 Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction

Li, C, Friedman, JM

Proc. Natl. Acad. Sci. U.S.A. 1999
Participants
Input
Output
Catalyst Activity

protein tyrosine kinase activity of Lep:Lepr:p-Jak2 [plasma membrane]

Physical Entity
Lep:Lepr:p-Jak2 [plasma membrane] (Mus musculus)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
JAK2 Phosphorylates LEPR (Homo sapiens)
Authored
May, B  (2012-11-15)
Reviewed
Scherer, T  (2013-08-31)
Gonzalez-Perez, RR  (2013-10-26)
Created
May, B  (2012-11-15)
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