Reactome | Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

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Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10100887
displayName	Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
eventOf	[Pathway:R-MMU-2142753] Arachidonate metabolism - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:9982] epoxygenase P450 pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-2161890] Arachidonate is epoxidated to 5,6-EET by CYP(4) - Mus musculus [Reaction:R-MMU-2161899] Arachidonate is epoxidated to 8,9-EET by CYP(5) - Mus musculus [Reaction:R-MMU-9915971] Arachidonate is epoxidated to 11,12-EET by CYP(5) - Mus musculus [Reaction:R-MMU-9915997] Arachidonate is epoxidated to 14,15-EET by CYP(5) - Mus musculus [Reaction:R-MMU-2161961] 5,6-EET is hydrolysed to 5,6-DHET by EPHX2 - Mus musculus [Reaction:R-MMU-9915968] 8,9-EET is hydrolysed to 8.9-DHET by EPHX2 - Mus musculus [Reaction:R-MMU-9915986] 11,12-EET is hydrolysed to 11,12-DHET by EPHX2 - Mus musculus [Reaction:R-MMU-9915994] 14,15-EET is hydrolysed to 14,15-DHET by EPHX2 - Mus musculus
inferredFrom	[Pathway:R-HSA-2142670] Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-2142670
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-2142753] Arachidonate metabolism
(inferredTo)	[Pathway:R-HSA-2142670] Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

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